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KMID : 1144320130450040431
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감염과 화학요법
2013 Volume.45 No. 4 p.431 ~ p.434
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High In Vitro Infectivity of a Doxycycline-Insensitive Strain of Orientia tsutsugamushi
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Kim Min-Su
Baek Ji-Hyeon
Chung Moon-Hyun
Lee Sun-Myoung
Kang Jae-Seung
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Abstract
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We compared the infectivity and growth rates of 12 strains of Orientia tsutsugamushi in a cell culture system. ECV304 cells were infected with O. tsutsugamushi strains for 4 hr, and the culture was maintained for 72 hr. Immunofluorescence (IF) staining was performed at 4, 24, 48, and 72 hr after inoculation (hpi), and IF-positive foci were enumerated. The AFSC-4 strain, which is known to be insensitive to doxycycline, showed higher numbers of IF-positive foci than the other 11 strains at 4, 24, 48, and 72 hpi, which may explain its apparent insensitivity to antibiotics.
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KEYWORD
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Orientia tsutsugamushi, Scrub typhus, Virulence, Drug resistance
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